(19)

(11)

EP 2 707 008 A1

(12)

(43) Date of publication: 19.03.2014 Bulletin 2014/12 (21) Application number: 12781877.1 (22) Date of filing: 11.05.2012

(51) International Patent Classification (IPC):  A61K 33/36(2006.01) A61P 43/00(2006.01) A61P 39/00(2006.01) (86) International application number: PCT/US2012/037560 (87) International publication number: WO 2012/155061 (15.11.2012 Gazette 2012/46)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR (30) Priority: 12.05.2011 US 201113106516 18.05.2011 US 201113110737 (71) Applicant: Board of Regents, The University of Texas System Austin, TX 78701 (US)	(72) Inventor: YUAN, Zhi-Min San Antonio Texas 78240 (US) (74) Representative: Harrison Goddard Foote LLP  Belgrave Hall Belgrave Street Leeds LS2 8DD Leeds LS2 8DD (GB)