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EP 2 709 447 A1

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(43) Date of publication: 26.03.2014 Bulletin 2014/13 (21) Application number: 11865780.8 (22) Date of filing: 17.05.2011

(51) International Patent Classification (IPC):  A01N 25/00(2006.01) A61L 9/02(2006.01) A61K 9/72(2006.01) (86) International application number: PCT/US2011/036868 (87) International publication number: WO 2012/158166 (22.11.2012 Gazette 2012/47)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME (71) Applicant: Pearl Therapeutics, Inc. Redwood City, CA 94063 (US)

(72) Inventors: VEHRING, Reinhard Edmonton, Alberta T63 0T1 (CA) HARTMAN, Michael, Steven Millbrae, California 94030 (US) LECHUGA-BALLESTEROS, David San Jose, California 95124 (US) SMITH, Adrian, Edward Emerald Hills, California 94062 (US) JOSHI, Vidya, B. Redwood City, California 94065 (US) DWIVEDI, Sarvajna, Kumar Redwood City, California 94065 (US) (74) Representative: Bennett, Nicholas et al Cleveland Reading 10 Fetter Lane London EC4A 1BR London EC4A 1BR (GB)