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(11)

EP 2 709 663 A2

(12)

(88) Date of publication A3: 21.03.2013 (43) Date of publication: 26.03.2014 Bulletin 2014/13 (21) Application number: 12790022.3 (22) Date of filing: 21.05.2012

(51) International Patent Classification (IPC):  A61K 39/395(2006.01) G01N 33/53(2006.01) A61P 35/00(2006.01) C07K 16/28(2006.01) A61P 27/02(2006.01) (86) International application number: PCT/US2012/038875 (87) International publication number: WO 2012/162257 (29.11.2012 Gazette 2012/48)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR (30) Priority: 20.05.2011 US 201161488660 P 14.06.2011 US 201161496860 P (71) Applicants: AlderBio Holdings LLC Las Vegas, NV 89109 (US) University of Iowa Research Foundation Iowa City, IA 52242-5500 (US)

(72) Inventors: RUSSO, Andrew F. Iowa City Iowa 52245 (US) KAISER, Eric A. Iowa City Iowa 52245 (US) RECOBER, Ana Iowa City Iowa 52240 (US) KUBURAS, Adisa North Liberty Iowa 52317 (US) RADDANT, Ann C. Iowa City Iowa 52246 (US) KOVACEVICH, Brian Robert Snohomish Washington 98296 (US) LATHAM, John A. Seattle Washington 98119 (US) SMITH, Jeffrey T.L. Bellevue Washington 98004 (US) GARCIA-MARTINEZ, Leon F. Woodinville Washington 98072 (US) (74) Representative: Stephens, Clare Jean  Page White & Farrer Bedford House John Street London WC1N 2BF London WC1N 2BF (GB)