(19)

(11)

EP 2 710 005 A1

(12)

(43) Date of publication: 26.03.2014 Bulletin 2014/13 (21) Application number: 12722662.9 (22) Date of filing: 16.05.2012

(51) International Patent Classification (IPC):  C07D 487/04(2006.01) A61P 35/00(2006.01) A61K 31/535(2006.01) (86) International application number: PCT/US2012/038092 (87) International publication number: WO 2012/158764 (22.11.2012 Gazette 2012/47)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR (30) Priority: 17.05.2011 US 201161486944 P 03.08.2011 US 201161514892 P 07.11.2011 US 201161556336 P 30.03.2012 US 201261618152 P (71) Applicant: Principia Biopharma Inc. So. San Francisco, California 94080 (US)	(72) Inventors: GOLDSTEIN, David Michael Redwood City California 94061 (US) BRAMELD, Kenneth Albert Menlo Park California 94027 (US) (74) Representative: Srinivasan, Ravi Chandran  J A Kemp 14 South Square Gray's Inn London WC1R 5JJ London WC1R 5JJ (GB)