(19)

(11)

EP 2 713 851 A1

(12)

(43) Date of publication: 09.04.2014 Bulletin 2014/15 (21) Application number: 11723853.5 (22) Date of filing: 31.05.2011

(51) International Patent Classification (IPC):  A61B 5/00(2006.01) A61B 1/012(2006.01) G02B 26/10(2006.01) A61B 1/00(2006.01) G01N 21/47(2006.01) (86) International application number: PCT/US2011/038593 (87) International publication number: WO 2012/166116 (06.12.2012 Gazette 2012/49)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR (71) Applicant: Vanderbilt University Nashville, Tennessee 37240 (US)	(72) Inventors: JOOS, Karen Nashville, TN 37205 (US) SHEN, Jin, Hui Nashville, TN 37212 (US) (74) Representative: Grünecker, Kinkeldey, Stockmair & Schwanhäusser  Leopoldstrasse 4 80802 München 80802 München (DE)