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EP 2 714 909 A1

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(43) Date of publication: 09.04.2014 Bulletin 2014/15 (21) Application number: 12796718.0 (22) Date of filing: 01.06.2012

(51) International Patent Classification (IPC):  C12N 15/12(2006.01) C07K 14/755(2006.01) A61P 7/04(2006.01) C12Q 1/68(2006.01) A61K 38/37(2006.01) (86) International application number: PCT/US2012/040376 (87) International publication number: WO 2012/170289 (13.12.2012 Gazette 2012/50)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR (30) Priority: 03.06.2011 US 201113153040 (71) Applicants: The Regents of The University of Michigan Ann Arbor, MI 48109-2590 (US) Inspiration Biopharmaceuticals, Inc. Laguna Niguel, CA 92677 (US)	(72) Inventors: KAUFMAN, Randal, J. San Diego, CA 92130 (US) PIPE, Steven, W. Ypsilanti, MI 48197 (US) GRIFFITH, Michael San Juan Capistrano, CA 92675 (US) (74) Representative: Gates, Marie Christina Esther et al Tomkins & Co. 5 Dartmouth Road Dublin 6 Dublin 6 (IE)