(19)
(11) EP 2 714 933 A2

(12)

(88) Date of publication A3:
28.03.2013

(43) Date of publication:
09.04.2014 Bulletin 2014/15

(21) Application number: 12789375.8

(22) Date of filing: 25.05.2012
(51) International Patent Classification (IPC): 
C12Q 1/68(2006.01)
G06F 17/10(2006.01)
 C12N 15/11(2006.01)
(86) International application number:
PCT/US2012/039699
(87) International publication number:
WO 2012/162660 (29.11.2012 Gazette 2012/48)
(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

(30) Priority: 25.05.2011 US 201161489883 P
20.07.2011 US 201161509644 P
12.01.2012 US 201261585892 P
03.04.2012 US 201261619663 P

(71) Applicants:
  • Brown University
    Providence, RI 02912 (US)
  • The Regents of The University of California
    Oakland, CA 94607 (US)

(72) Inventors:
  • KELSEY, Karl
    Brookline Massachusetts 02446 (US)
  • HOUSEMAN, Eugene, Andres
    Albany Oregon 97321 (US)
  • WIENCKE, John
    San Francisco California 94116 (US)
  • ACCOMANDO, William, P., Jr.
    Providence Rhode Island 02906 (US)
  • MARSIT, Carmen
    Grantham New Hampshire 03753 (US)

(74) Representative: WP Thompson 
Coopers Building Church Street
Liverpool L1 3AB
Liverpool L1 3AB (GB)

   


(54) METHODS USING DNA METHYLATION FOR IDENTIFYING A CELL OR A MIXTURE OF CELLS FOR PROGNOSIS AND DIAGNOSIS OF DISEASES, AND FOR CELL REMEDIATION THERAPIES