(19)
(11) EP 2 716 758 A8

(12) CORRECTED EUROPEAN PATENT APPLICATION
published in accordance with Art. 153(4) EPC

(15) Correction information:
Corrected version no 1 (W1 A1)

(48) Corrigendum issued on:
25.06.2014 Bulletin 2014/26

(88) Date of publication A3:
09.04.2014 Bulletin 2014/15

(43) Date of publication:
09.04.2014 Bulletin 2014/15

(21) Application number: 12792620.2

(22) Date of filing: 01.06.2012
(51) International Patent Classification (IPC): 
C12N 15/09(2006.01)
A61K 48/00(2006.01)
G01N 33/53(2006.01)
 A61K 31/7088(2006.01)
C12N 15/113(2010.01)
(86) International application number:
PCT/JP2012/064276
(87) International publication number:
WO 2012/165616 (06.12.2012 Gazette 2012/49)
(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

(30) Priority: 03.06.2011 JP 2011125734

(71) Applicant: National University Corporation Hokkaido University
Sapporo-shi, Hokkaido 060-0808 (JP)

(72) Inventors:
  • MATSUDA Akira
    Sapporo-shi Hokkaido 060-0808 (JP)
  • TAKAHASHI Mayumi
    Sapporo-shi Hokkaido 060-0808 (JP)

(74) Representative: Katzameyer, Michael 
v. Bezold & Partner Patentanwälte Akademiestrasse 7
80799 München
80799 München (DE)

   


(54) OLIGONUCLEOTIDE DERIVATIVE, OLIGONUCLEOTIDE DERIVATIVE-CONTAINING PHARMACEUTICAL COMPOSITION FOR TREATMENT AND PHARMACEUTICAL COMPOSITION FOR DIAGNOSIS, AND OLIGONUCLEOTIDE DERIVATIVE FOR REGULATION OF miRNA FUNCTION


(57) An oligonucleotide derivative comprises repeating structural units represented by the following general formula (wherein B represents adenine, guanine, cytosine, or uracil; X represents a sulfur atom or an oxygen atom; n represents an integer of 6 to 60; and B and X are independently represented in each of the repeating structural units), wherein X is a sulfur atom in at least one of the repeating structural units represented by the general formula: