| (19) |
 |
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(11) |
EP 2 720 043 A3 |
| (12) |
EUROPEAN PATENT APPLICATION |
| (88) |
Date of publication A3: |
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20.08.2014 Bulletin 2014/34 |
| (43) |
Date of publication A2: |
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16.04.2014 Bulletin 2014/16 |
| (22) |
Date of filing: 10.03.2011 |
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| (51) |
International Patent Classification (IPC):
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| (84) |
Designated Contracting States: |
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AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL
NO PL PT RO RS SE SI SK SM TR |
| (30) |
Priority: |
10.03.2010 EP 10290124
|
| (62) |
Application number of the earlier application in accordance with Art. 76 EPC: |
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11710151.9 / 2545380 |
| (71) |
Applicant: INSTITUT PASTEUR |
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75724 Paris Cedex 15 (FR) |
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| (72) |
Inventors: |
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- Gougeon, Marie-Lise
92140 Clamart (FR)
- Poirier-Beaudouin, Béatrice
78650 Beynes (FR)
- Seffer, Valérie
91800 Brunoy (FR)
- Saidi, Héla
94800 Villejuif (FR)
|
| (74) |
Representative: Desaix, Anne et al |
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Ernest Gutmann - Yves Plasseraud SAS
3, rue Auber
75009 Paris
75009 Paris (FR) |
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| |
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| (54) |
HMGB1 and anti-HMGB1 antibodies for the prognosis of neurological disorders |
(57) The invention relates to
in vitro method for quantitating the antibodies specific for High mobility group box I (HMGB1)
contained in a sample, in particular a serum sample or a cerebrospinal fluid sample
obtained from a patient, and the use of this method in the prognostic and/or diagnosis
of neurological disorders. These methods are in particular applicable to the monitoring
of the human immunodeficiency virus (HIV) infection of a subject who is known to be
infected with HIV and in the prognostic and/or diagnostic of the state of progression
of Acquired immune deficiency syndrome (AIDS) or the state of progression toward AIDS,
in particular the state of progression or the state of progression toward neurological
disorders associated with AIDS. Finally, the invention is also about method to determine
the immune deficiency or level of immune activation of a patient, in particular a
HIV-infected patient.