(19)

(11)

EP 2 720 703 A1

(12)

(43) Date of publication: 23.04.2014 Bulletin 2014/17 (21) Application number: 12800695.4 (22) Date of filing: 15.06.2012

(51) International Patent Classification (IPC):  A61K 38/00(2006.01) A61P 3/00(2006.01) C12N 9/00(2006.01) A61K 38/43(2006.01) A61P 5/50(2006.01) C12Q 1/00(2006.01) (86) International application number: PCT/US2012/042636 (87) International publication number: WO 2012/174359 (20.12.2012 Gazette 2012/51)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR (30) Priority: 17.06.2011 US 201161498202 P 30.09.2011 US 201161541686 P (71) Applicant: The Johns Hopkins University Baltimore, MD 21218 (US)	(72) Inventors: POWELL, Jonathan, David Baltimore, MD 21218 (US) XIAO, Bo Ellicott City, MD 21043 (US) WORLEY, Paul, F. Baltimore, MD 21218 (US) DELGOFFE, Greg, Michael Memphis, TN 38112 (US) WAICKMAN, Adam Elkridge, MD 21075 (US) (74) Representative: Sutcliffe, Nicholas Robert  Mewburn Ellis LLP 33 Gutter Lane London EC2V 8AS London EC2V 8AS (GB)