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EP 2 721 019 A1

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(43) Date of publication: 23.04.2014 Bulletin 2014/17 (21) Application number: 12800001.5 (22) Date of filing: 18.06.2012

(51) International Patent Classification (IPC):  C07D 401/04(2006.01) C07D 401/14(2006.01) A61K 31/44(2006.01) A61P 35/00(2006.01) C07D 401/02(2006.01) C07D 405/00(2006.01) A61K 31/4427(2006.01) (86) International application number: PCT/CN2012/000841 (87) International publication number: WO 2012/171337 (20.12.2012 Gazette 2012/51)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME (30) Priority: 17.06.2011 CN 201110172169 18.07.2011 US 201161509071 P 06.01.2012 US 201261584210 P (71) Applicant: Agios Pharmaceuticals, Inc. Cambridge, MA 02139 (US)

(72) Inventors: CAO, Sheldon San Diego, CA 92130 (US) POPOVICI-MULLER, Janeta Windham, NH 03087 (US) SALITURO, Francesco G. Marlborough, MA 01752 (US) SAUNDERS, Jeffrey, O. Lincoln, MA 01773 (US) TRAVINS, Jeremy Southborough, MA 01772 (US) TAN, Xuefei Shanghai 200135 (CN) YAN, Shunqi Irvine, CA 92603 (US) YE, Zhixiong West Windsor, NJ 08550 (US) (74) Representative: Bösl, Raphael Konrad  Isenbruck Bösl Hörschler LLP Patentanwälte Prinzregentenstrasse 68 81675 München 81675 München (DE)