(19)

(11)

EP 2 723 349 A2

(12)

(88) Date of publication A3: 28.02.2013 (43) Date of publication: 30.04.2014 Bulletin 2014/18 (21) Application number: 12804592.9 (22) Date of filing: 26.06.2012

(51) International Patent Classification (IPC):  A61K 31/7088(2006.01) C12N 15/113(2010.01) (86) International application number: PCT/US2012/044197 (87) International publication number: WO 2013/003346 (03.01.2013 Gazette 2013/01)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR (30) Priority: 27.06.2011 US 201161501482 P (71) Applicants: MedImmune, LLC Gaithersburg, MD 20878 (US) Shanghai Renji Hospital Shanghai 200001 (CN)	(72) Inventors: YAO, Yihong Gaithersburg, MD 20878 (US) SHEN, Nan Shanghai 200001 (CN) FAN, Wei Xiamen City (CN) TANG, Yuanjia Shanghai 200025 (CN) (74) Representative: Winter, Christopher Spencer  Medlmmune Limited Intellectual Property Milstein Building Granta Park Cambridge, Cambridgeshire CB21 6GH Cambridge, Cambridgeshire CB21 6GH (GB)