(19)
(11) EP 2 729 138 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
28.02.2018 Bulletin 2018/09

(45) Mention of the grant of the patent:
13.12.2017 Bulletin 2017/50

(21) Application number: 12735494.2

(22) Date of filing: 04.07.2012
(51) International Patent Classification (IPC): 
A61K 31/121(2006.01)
A61P 25/08(2006.01)
A61P 25/18(2006.01)
A61K 36/9066(2006.01)
A61P 25/28(2006.01)
(86) International application number:
PCT/EP2012/063027
(87) International publication number:
WO 2013/004740 (10.01.2013 Gazette 2013/02)

(54)

ANTICONVULSANT ACTIVITY OF BISABOLENE SESQUITERPENOIDS ISOLATED FROM TURMERIC OIL

KRAMPFLÖSENDE WIRKUNG VON BISABOLEN-SESQUITERPENOIDEN AUS CURCUMAÖL

ACTIVITÉ ANTI-CONVULSION DE BISABOLÈNE SESQUITERPÉNOÏDES D'HUILE DE CURCUMA


(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

(30) Priority: 04.07.2011 GB 201111319

(43) Date of publication of application:
14.05.2014 Bulletin 2014/20

(73) Proprietors:
  • De Witte, Peter, A. M.
    3010 Kessel-Lo (BE)
  • Esguerra, Camila, V.
    3020 Herent (BE)
  • Crawford, Alexander D.
    3020 Herent (BE)
  • Orellana Paucar, Adriana Monserrath
    010104 Cuenca (EC)
  • Universidad de Cuenca
    Cuenca (EC)

(72) Inventors:
  • DE WITTE, Peter, A. M.
    3010 Kessel-Lo (BE)
  • ESGUERRA, Camila, V.
    3020 Herent (BE)
  • CRAWFORD, Alexander D.
    3020 Herent (BE)
  • ORELLANA PAUCAR, Adriana Monserrath
    010104 Cuenca (EC)

(74) Representative: Grund, Martin 
Grund Intellectual Property Group Patentanwalt und Solicitor PartG mbB Postfach 44 05 16
80754 München
80754 München (DE)


(56) References cited: : 
WO-A1-2011/014880
WO-A2-2010/045577
WO-A2-2011/125070
WO-A2-03/051380
WO-A2-2011/114350
   
  • FUJIWARA, MAI ET AL: "Acetylcholinesterase Inhibitory Activity of Volatile Oil from Peltophorum dasyrachis Kurz ex Bakar (Yellow Batai) and Bisabolane-Type Sesquiterpenoids", JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, vol. 58, no. 5, 2010, pages 2824-2829, XP007920903, ISSN: 0021-8561
  • PARK SO-YOUNG ET AL: "Discovery of natural products from Curcuma longa that protect cells from beta-amyloid insult: a drug discovery effort against Alzheimer's disease", JOURNAL OF NATURAL PRODUCTS, vol. 65, no. 9, 1 September 2002 (2002-09-01), pages 1227-1231, XP002551937, AMERICAN CHEMICAL SOCIETY, US ISSN: 0163-3864, DOI: 10.1021/NP010039X
  • AHMED T ET AL: "Inhibitory effect of curcuminoids on acetylcholinesterase activity and attenuation of scopolamine-induced amnesia may explain medicinal use of turmeric in Alzheimer's disease", PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, vol. 91, no. 4, 1 February 2009 (2009-02-01), pages 554-559, XP025880968, ELSEVIER, US ISSN: 0091-3057, DOI: 10.1016/J.PBB.2008.09.010 [retrieved on 2008-10-01]
  • DATABASE EPODOC [Online] EUROPEAN PATENT OFFICE, THE HAGUE, NL; 18 June 2006 (2006-06-18), WANG W; YAN L; ZHANG T: "Compound essential oil of releasing arthritis ache", XP002681171, Database accession no. CN-200710303694-A & CN 101 199 833 B (BEIJING ZHONGKE YONGHE MEDICAL [CN] BEIJING ZHONGKE YONGHE MEDICAL TEC) 16 March 2011 (2011-03-16)
  • CRAWFORD A D ET AL: "Fishing for drugs from nature: Zebrafish as a technology platform for natural product discovery", PLANTA MEDICA, vol. 74, no. 6, May 2008 (2008-05), pages 624-632, XP007920902, DE ISSN: 0032-0943, DOI: 10.1055/S-2008-1034374
  • ORELLANA-PAUCAR A M ET AL: "Anticonvulsant activity of bisabolene sesquiterpenoids of Curcuma longa in zebrafish and mouse seizure models", EPILEPSY AND BEHAVIOR, vol. 24, no. 1, May 2012 (2012-05), pages 14-22, XP007920901, ACADEMIC PRESS INC. USA ISSN: 1525-5050, DOI: 10.1016/J.YEBEH.2012.02.020
   
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