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(11)

EP 2 731 434 A1

(12)

(43) Date of publication: 21.05.2014 Bulletin 2014/21 (21) Application number: 12811164.8 (22) Date of filing: 10.07.2012

(51) International Patent Classification (IPC):  A01N 43/04(2006.01) A61K 31/415(2006.01) A01N 43/52(2006.01) C07H 19/04(2006.01) (86) International application number: PCT/US2012/046035 (87) International publication number: WO 2013/009735 (17.01.2013 Gazette 2013/03)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR (30) Priority: 13.07.2011 US 201161507386 P (71) Applicant: Merck Sharp & Dohme Corp. Rahway, NJ 07065-0907 (US)

(72) Inventors: VERMA, Vishal Kenilworth, New jersey 07033 (US) ARASAPPAN, Ashok Kenilworth, New Jersey 07033 (US) NJOROGE, F. George Kenilworth, New Jersey 07033 (US) GIRI-JAVALLABHAN, Vinay Kenilworth, New Jersey 07033 (US) BOGEN, Stephane, L. Rahway, NJ 07065-0907 (US) DANG, Qun Rahway, NJ 07065-0907 (US) OLSEN, David, B. West Point, PA 19486 (US) (74) Representative: Böhles, Elena  Merck & Co., Inc. Hertford Road Hoddesdon, Hertfordshire EN11 9BU Hoddesdon, Hertfordshire EN11 9BU (GB)