(19)

(11)

EP 2 734 497 A1

(12)

(43) Date of publication: 28.05.2014 Bulletin 2014/22 (21) Application number: 12740703.9 (22) Date of filing: 20.07.2012

(51) International Patent Classification (IPC):  C07C 65/19(2006.01) C07C 229/08(2006.01) A61K 31/166(2006.01) A61K 31/192(2006.01) A61K 31/235(2006.01) C07C 69/76(2006.01) C07C 235/42(2006.01) A61K 31/167(2006.01) A61K 31/205(2006.01) A61P 29/00(2006.01) (86) International application number: PCT/IE2012/000038 (87) International publication number: WO 2013/014660 (31.01.2013 Gazette 2013/05)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME (30) Priority: 22.07.2011 US 201161510675 P 24.05.2012 US 201261651155 P (71) Applicant: Venantius Limited Dublin 2 (IE)	(72) Inventors: SHERIDAN, Helen Dublin 14 (IE) FRANKISH, Neil Dublin 14 (IE) (74) Representative: O'Brien, John Augustine et al John A. O'Brien & Associates, Third Floor, Duncairn House, 14 Carysfort Avenue Blackrock, County Dublin Blackrock, County Dublin (IE)