(19)

(11)

EP 2 736 536 A2

(12)

(88) Date of publication A3: 25.04.2013 (43) Date of publication: 04.06.2014 Bulletin 2014/23 (21) Application number: 12818108.8 (22) Date of filing: 26.07.2012

(51) International Patent Classification (IPC):  A61K 47/48(2006.01) A61K 9/16(2006.01) A61P 3/10(2006.01) A61K 47/30(2006.01) A61K 9/00(2006.01) (86) International application number: PCT/US2012/048352 (87) International publication number: WO 2013/016544 (31.01.2013 Gazette 2013/05)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR (30) Priority: 27.07.2011 US 201161512303 P 29.05.2012 US 201213482671 (71) Applicant: University Of Kansas Lawrence, KS 66045 (US)	(72) Inventors: STEHNO-BITTEL, Lisa, A. Bonner Springs Kansas 66012 (US) RAMACHANDRAN, Karthik Kansas City Kansas 66103 (US) (74) Representative: Hally, Anna-Louise  FRKelly 27 Clyde Road Dublin 4 Dublin 4 (IE)