(19)
(11) EP 2 736 903 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
19.04.2017 Bulletin 2017/16

(45) Mention of the grant of the patent:
22.06.2016 Bulletin 2016/25

(21) Application number: 12820561.4

(22) Date of filing: 27.07.2012
(51) International Patent Classification (IPC): 
C07H 17/04(2006.01)
A61K 31/7048(2006.01)
C07D 407/04(2006.01)
A61P 31/18(2006.01)
(86) International application number:
PCT/US2012/048657
(87) International publication number:
WO 2013/019662 (07.02.2013 Gazette 2013/06)

(54)

ARYL NAPHTHALIDE LIGNANS AS ANTI-HIV AGENTS

ARYL-NAPHTHALID-LIGNANE ALS ANTI-HIV-WIRKSTOFFE

LIGNANES DE NAPHTALIDE D'ARYLE EN TANT QU'AGENTS ANTI-VIH


(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

(30) Priority: 29.07.2011 US 201161513119 P

(43) Date of publication of application:
04.06.2014 Bulletin 2014/23

(73) Proprietors:
  • The Board of Trustees of the University of Illinois
    Urbana, IL 61801 (US)
  • Hong Kong Baptist University
    Hong Kong (CN)

(72) Inventors:
  • ZHANG, Hongjie
    Hong Kong (CN)
  • SOEJARTO, Djaja
    Lombard, Illinois 60148 (US)
  • RONG, Lijun
    Westmont, Illinois 60559 (US)
  • FONG, Harry HS
    Glen Ellyn, Illinois 60137 (US)
  • RUMSCHLAG-BOOMS, Emily
    Chicago, Illinois 60647 (US)

(74) Representative: Guardian IP Consulting I/S 
Diplomvej, Building 381
2800 Kgs. Lyngby
2800 Kgs. Lyngby (DK)


(56) References cited: : 
US-A1- 2005 013 879
US-A1- 2008 167 353
   
  • A. S. R. ANJANEYULU ET AL: "New lignans from the heartwood of Cleistanthus collinus", TETRAHEDRON, vol. 37, no. 21, 1981, pages 3641-3652, XP002502258, ISSN: 0040-4020, DOI: 10.1016/S0040-4020(01)98893-3
  • PATOOMRATANA TUCHINDA ET AL: "Cytotoxic arylnaphthalide lignan glycosides from the aerial parts of Phyllanthus taxodiifolius", PLANTA MEDICA, vol. 72, no. 1, 2006, pages 60-62, XP055154802, ISSN: 0032-0943, DOI: 10.1055/s-2005-87314
  • JUNMIAN TIAN ET AL: "A new lignan and four new lignan glycosides from Mananthes patentiflora", HELVETICA CHIMICA ACTA, vol. 89, no. 2, 2006, pages 291-298, XP055154503, ISSN: 0018-019X, DOI: 10.1002/hlca.200690033
  • CHIA-WEN CHANG ET AL: "Differential inhibition of reverse transcriptase and cellular DNA polymerase-[alpha] activities by lignans isolated from Chinese herbs, Phyllanthus myrtifolius Moon, and tannins from Lonicera japonica Thunb and Castanopsis hystrix", ANTIVIRAL RESEARCH, vol. 27, no. 4, 1995, pages 367-374, XP055154716, ISSN: 0166-3542, DOI: 10.1016/0166-3542(95)00020-M
  • SHOEI-SHENG LEE ET AL: "Six lignans from Phyllanthus myrtifolius", JOURNAL OF NATURAL PRODUCTS, vol. 59, no. 11, 1996, pages 1061-1065, XP002732975, DOI: 10.1021/np960322+
  • KADALI S. SAGAR ET AL: "Preparation and anti-HIV activities of retrojusticidin B analogs and azalignans", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 12, no. 15, 2004, pages 4045-4054, XP055005478, ISSN: 0968-0896, DOI: 10.1016/j.bmc.2004.05.036
  • PATOOMRATANA TUCHINDA ET AL: "Dichapetalin-type triterpenoids and lignans from the aerial parts of Phyllanthus acutissima", JOURNAL OF NATURAL PRODUCTS, vol. 71, no. 4, 2008, pages 655-663, XP055154519, ISSN: 0163-3864, DOI: 10.1021/np7007347
  • ZHAO, Y. ET AL.: 'First synthesis of bioactive diphyllin glycosides isolated from justicia patentiflor hemsl' CHINESE JOURNAL OF CHEMISTRY vol. 25, 2007, pages 679 - 682, XP055143290
  • SUSPLUGAS, S. ET AL.: 'Cytotoxic arylnaphthalene lignans from a vietnamese acanthaceae, Justicia patentiflora' JOURNAL OF NATURAL PRODUCTS vol. 68, 2005, pages 734 - 738, XP055143295
   
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