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EP 2 742 056 A1

(12)

(43) Date of publication: 18.06.2014 Bulletin 2014/25 (21) Application number: 12822510.9 (22) Date of filing: 08.08.2012

(51) International Patent Classification (IPC):  C07H 21/00(2006.01) A61K 31/7088(2006.01) C12N 15/113(2010.01) (86) International application number: PCT/US2012/050015 (87) International publication number: WO 2013/022984 (14.02.2013 Gazette 2013/07)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR (30) Priority: 11.08.2011 US 201161522659 P 08.02.2012 US 201261596723 P 24.02.2012 US 201261603196 P (71) Applicant: Isis Pharmaceuticals, Inc. Carlsbad, CA 92010 (US)	(72) Inventors: SETH, Punit, P. Carlsbad, CA 92010 (US) OESTERGAARD, Michael Carlsbad, CA 92010 (US) SWAYZE, Eric, E. Carlsbad, CA 92010 (US) (74) Representative: Carpmaels & Ransford LLP  One Southampton Row London WC1B 5HA London WC1B 5HA (GB)