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(11)

EP 2 744 831 A2

(12)

(88) Date of publication A3: 02.05.2013 (43) Date of publication: 25.06.2014 Bulletin 2014/26 (21) Application number: 12824616.2 (22) Date of filing: 15.08.2012

(51) International Patent Classification (IPC):  C07K 19/00(2006.01) C12N 15/63(2006.01) C12N 15/62(2006.01) A61K 38/40(2006.01) (86) International application number: PCT/US2012/051013 (87) International publication number: WO 2013/025846 (21.02.2013 Gazette 2013/08)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR (30) Priority: 17.08.2011 US 201161524508 P (71) Applicant: The Regents of the University of Colorado, A Body Corporate Denver, CO 80203 (US)	(72) Inventors: KOMPELLA, Uday B. Englewood, CO 80111 (US) SCHEINMAN, Robert I. Conifer, CO 80433 (US) TYAGI, Puneet Denver, CO 80220 (US) (74) Representative: ZBM Patents - Zea, Barlocci & Markvardsen  Zea, Barlocci & Markvardsen Plaza Catalunya, 1 08002 Barcelona 08002 Barcelona (ES)