(19)
(11) EP 2 752 495 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
29.04.2020 Bulletin 2020/18

(45) Mention of the grant of the patent:
25.03.2020 Bulletin 2020/13

(21) Application number: 12818440.5

(22) Date of filing: 16.07.2012
(51) International Patent Classification (IPC): 
C12Q 1/56(2006.01)
G01N 21/64(2006.01)
G01N 21/76(2006.01)
G01N 33/48(2006.01)
(86) International application number:
PCT/RU2012/000570
(87) International publication number:
WO 2013/015717 (31.01.2013 Gazette 2013/05)

(54)

METHOD FOR DETERMINING THE ACTIVITY OF A PROTEOLYTIC ENZYME (VARIANTS), DEVICE FOR THE IMPLEMENTATION OF SAME AND DIAGNOSTIC METHOD

VERFAHREN ZUR BESTIMMUNG DER AKTIVITÄT EINES PROTEOLYTISCHEN ENZYMS (VARIANTEN), VORRICHTUNG ZUR UMSETZUNG DES VERFAHRENS UND DIAGNOSEVERFAHREN

PROCÉDÉ DE DÉTERMINATION DE L'ACTIVITÉ D'UNE ENZYME PROTÉOLYTIQUE (VARIANTES), DISPOSITIF POUR LA MISE EN OEUVRE DE CELUI-CI ET PROCÉDÉ DE DIAGNOSTIC


(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

(30) Priority: 26.07.2011 RU 2011131293

(43) Date of publication of application:
09.07.2014 Bulletin 2014/28

(73) Proprietor: Obschestvo S Ogranichennoy Otvetstvennostyu «Gematologicheskaya Korporatsiya»
Moscow 117246 (RU)

(72) Inventors:
  • ATAULLAKHANOV, Fazoil Inoyatovichon
    Moscow 115419 (RU)
  • DASHKEVICH, Nataljya Mikhajlovna
    Pyschino Moscow region 142290 (RU)
  • OVANESOV, Mikhail Vladimirovich
    Zelenograd 124460 (RU)
  • SARBASH, Vasilii Ivanovich
    Moscow 105066 (RU)
  • PANTELEEV, Mikhail Aleksandrovich
    Mytishchi 141004 (RU)
  • KARAMZIN, Sergey Sergeevich
    Moscow 117279 (RU)
  • KONDRATOVICH, Andrey Yurjevich
    Moscow 123060 (RU)

(74) Representative: Grimm, Siegfried 
E. Blum & Co. AG Vorderberg 11
8044 Zürich
8044 Zürich (CH)


(56) References cited: : 
WO-A1-93/10261
WO-A1-2009/098313
US-A- 5 339 830
WO-A1-2009/055940
US-A- 5 059 525
   
  • KASTRUP C J ET AL: "Modular chemical mechanism predicts spatiotemporal dynamics of initiation in the complex network of hemostasis", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, NATIONAL ACADEMY OF SCIENCES, US, vol. 103, no. 43, 24 October 2006 (2006-10-24), pages 15747-15752, XP002539522, ISSN: 0027-8424, DOI: 10.1073/PNAS.0605560103
  • SHEN F ET AL: "Threshold response of initiation of blood coagulation by tissue factor in patterned microfluidic capillaries is controlled by shear rate", ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY, LIPPINCOTT WILLIAMS & WILKINS, US, vol. 28, no. 11, 1 November 2008 (2008-11-01), pages 2035-2041, XP009120847, ISSN: 1079-5642, DOI: 10.1161/ATVBAHA.108.173930 [retrieved on 2008-08-14]
  • SHIBEKO ALEXEY M ET AL: "Blood flow controls coagulation onset via the positive feedback of factor VII activation by factor Xa", BMC SYSTEMS BIOLOGY, BIOMED CENTRAL LTD, LO, vol. 4, no. 1, 26 January 2010 (2010-01-26), page 5, XP021069721, ISSN: 1752-0509
  • KONDRATOVICH A.Y. ET AL.: 'Spatiotemporal dynamics of contact activation factors of blood coagulation.' BIOCHIMICA ET BIOPHYSICA ACTA vol. 1569, no. 1-3, 2002, pages 86 - 104, XP004341305
  • FADEEVA O.A. ET AL.: 'Thromboplastin immobilized on polystyrene surface exhibits kinetic characteristics close to those for the native protein and activates in vitro blood coagulation similarly to thromboplastin on fibroblasts.' BIOCHEMISTRY vol. 75, no. 6, June 2010, MOSCOW, pages 734 - 743, XP055143074
 
Remarks:
The file contains technical information submitted after the application was filed and not included in this specification
 
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