(19)

(11)

EP 2 753 363 A2

(12)

(88) Date of publication A3: 02.05.2013 (43) Date of publication: 16.07.2014 Bulletin 2014/29 (21) Application number: 12829354.5 (22) Date of filing: 06.09.2012

(51) International Patent Classification (IPC):  A61K 48/00(2006.01) A61K 31/7088(2006.01) A61P 9/00(2006.01) A61K 31/105(2006.01) A61P 11/00(2006.01) (86) International application number: PCT/US2012/053920 (87) International publication number: WO 2013/036610 (14.03.2013 Gazette 2013/11)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR (30) Priority: 07.09.2011 US 201161531708 P (71) Applicant: University Of Medicine And Dentistry Of New Jersey Somerset, NJ 08873 (US)	(72) Inventors: MA, Jianjie Powell, OH 43065 (US) WEISLEDER, Noah Bexley, OH 43209 (US) (74) Representative: Helbig, Christian  Wagner + Helbig Patentanwälte Pfarrstrasse 14 80538 München 80538 München (DE)