(19)

(11)

EP 2 755 654 A1

(12)

(43) Date of publication: 23.07.2014 Bulletin 2014/30 (21) Application number: 12766542.0 (22) Date of filing: 14.09.2012

(51) International Patent Classification (IPC):  A61K 31/4196(2006.01) A61K 31/519(2006.01) A61K 31/498(2006.01) A61P 35/00(2006.01) (86) International application number: PCT/US2012/055387 (87) International publication number: WO 2013/040337 (21.03.2013 Gazette 2013/12)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME (30) Priority: 14.09.2011 US 201161534836 P 05.10.2011 US 201161543529 P 22.11.2011 US 201161562670 P (71) Applicants: Exelixis, Inc. South San Francisco, CA 94080 (US) SANOFI 75008 Paris (FR)	(72) Inventors: DECILLIS, Arthur Madison, CT 06443 (US) RUIZ SOTO, Rodrigo Boston, MA 02118 (US) EMMONS, Gary, Thomas Washington, NJ 07882 (US) LAGER, Joanne Hollis, NH 03049 (US) (74) Representative: Main, Malcolm Charles  Murgitroyd & Company Scotland House 165-169 Scotland Street Glasgow G5 8PL Glasgow G5 8PL (GB)