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(11)

EP 2 758 370 A1

(12)

(43) Date of publication: 30.07.2014 Bulletin 2014/31 (21) Application number: 12753948.4 (22) Date of filing: 29.08.2012

(51) International Patent Classification (IPC):  C07C 317/44(2006.01) A61K 31/495(2006.01) A61P 35/00(2006.01) C07D 237/18(2006.01) A61K 31/167(2006.01) (86) International application number: PCT/EP2012/066721 (87) International publication number: WO 2013/030205 (07.03.2013 Gazette 2013/10)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR (30) Priority: 01.09.2011 US 201161529942 P (71) Applicant: F.Hoffmann-La Roche AG 4070 Basel (CH)	(72) Inventors: HAYNES, Nancy-Ellen Cranford, New Jersey 07016 (US) HUBY, Nicholas John Silvester Scotch Plains, New Jersey 07076 (US) SCOTT, Nathan Robert Livingston, New Jersey 07039 (US) (74) Representative: Müller-Afraz, Simona  F. Hoffmann-La Roche AG CLP - Patent Department Grenzacherstrasse 124 4070 Basel 4070 Basel (CH)