| (84) |
Designated Contracting States: |
|
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL
NO PL PT RO RS SE SI SK SM TR |
| (30) |
Priority: |
14.10.2011 US 201161547166 P 20.06.2012 US 201261662163 P
|
| (43) |
Date of publication of application: |
|
27.08.2014 Bulletin 2014/35 |
| (73) |
Proprietors: |
|
- The Board of Trustees of the
University of Illinois
Urbana, IL 61801 (US)
- The Board of Regents of The University of Texas
System
Austin, TX 78701 (US)
|
|
| (72) |
Inventors: |
|
- HERGENROTHER, Paul J.
Champaign,
Illinois 61822 (US)
- BOOTHMAN, David A.
Dallas,
Texas 75230 (US)
- BAIR, Joseph S.
Albany,
California 94706 (US)
- PALCHAUDHURI, Rahul
Cambridge ,
Massachusetts 02139 (US)
- PARKINSON, Elisabeth I.
Champaign,
Illinois 61820 (US)
|
| (74) |
Representative: FRKelly |
|
27 Clyde Road Dublin D04 F838 Dublin D04 F838 (IE) |
| (56) |
References cited: :
WO-A2-2012/085532 US-A- 5 716 963
|
US-A- 4 906 562
|
|
| |
|
|
- PEREZ J M ET AL: "Concise Preparation of 1,8-Diazaanthracene-2,7,9,10-Tetraones. Two
Alternative Syntheses of the Natural Antifolate Diazaquinomycin A", TETRAHEDRON, ELSEVIER
SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 56, no. 26, 1 June 2000 (2000-06-01), pages
4575-4583, XP004202151, ISSN: 0040-4020, DOI: 10.1016/S0040-4020(00)00371-9
- JOSEPH S. BAIR ET AL: "Chemistry and Biology of Deoxynyboquinone, a Potent Inducer
of Cancer Cell Death", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 132, no. 15,
21 April 2010 (2010-04-21), pages 5469-5478, XP055187222, ISSN: 0002-7863, DOI: 10.1021/ja100610m
- X. HUANG ET AL: "An NQO1 Substrate with Potent Antitumor Activity That Selectively
Kills by PARP1-Induced Programmed Necrosis", CANCER RESEARCH, vol. 72, no. 12, 15
June 2012 (2012-06-15) , pages 3038-3047, XP055187225, ISSN: 0008-5472, DOI: 10.1158/0008-5472.CAN-11-3135
- DIAZ-GUERRA LUIS M ET AL: "Half-wave potentials of 1-aza and 1,8-diazaanthraquinones",
CAPLUS,, 1 January 1995 (1995-01-01), XP002480321,
- LI ET AL.: 'Modulating Endogenous NQ01 Levels Identifies Key Regulatory Mechanisms
of Action of b-Lapachone for Pancreatic Cancer Therapy' CLIN CANCER RES vol. 17, no.
2, 15 January 2011, pages 275 - 285, XP055096513
|
|