| (84) |
Designated Contracting States: |
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AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL
NO PL PT RO RS SE SI SK SM TR |
| (30) |
Priority: |
18.10.2011 EP 11306348
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| (43) |
Date of publication of application: |
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27.08.2014 Bulletin 2014/35 |
| (60) |
Divisional application: |
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19215890.5 |
| (73) |
Proprietors: |
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- Institut national de recherche pour l'agriculture,
l'alimentation et l'environnement
75338 Paris Cedex 07 (FR)
- The Royal Institution for the Advancement of
Learning / McGill University
Montréal, Québec H3A 2T5 (CA)
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| (72) |
Inventors: |
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- LESPINE, Anne
F-31000 Toulouse (FR)
- PRICHARD, Roger
F-31300 Toulouse (FR)
- MENEZ, Cécile
31 027 Toulouse Cedex 3 (FR)
|
| (74) |
Representative: Schiweck Weinzierl Koch
Patentanwälte Partnerschaft mbB |
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Ganghoferstraße 68 B 80339 München 80339 München (DE) |
| (56) |
References cited: :
EP-A1- 1 632 498
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WO-A1-01/70028
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- SHERIFF J C ET AL: "Effects of macrocyclic lactone anthelmintics on feeding and pharyngeal
pumping in Trichostrongylus colubriformis in vitro", PARASITOLOGY, CAMBRIDGE UNIVERSITY
PRESS, LONDON, GB, vol. 125, no. 5, 1 November 2002 (2002-11-01), pages 477-484, XP009157239,
ISSN: 0031-1820, DOI: 10.1017/S0031182002002251 [retrieved on 2003-01-17]
- LESPINE A ET AL: "ABC transporter modulation: a strategy to enhance the activity of
macrocyclic lactone anthelmintics", TRENDS IN PARASITOLOGY, ELSEVIER CURRENT TRENDS,
GB, vol. 24, no. 7, 1 July 2008 (2008-07-01), pages 293-298, XP022763105, ISSN: 1471-4922,
DOI: 10.1016/J.PT.2008.03.011 [retrieved on 2008-05-29]
- LESPINE A ET AL: "Interaction of ivermectin with multidrug resistance proteins (MRP1,
2 and 3)", CHEMICO-BIOLOGICAL INTERACTIONS, ELSEVIER SCIENCE IRLAND, IR, vol. 159,
no. 3, 25 February 2006 (2006-02-25), pages 169-179, XP025058319, ISSN: 0009-2797,
DOI: 10.1016/J.CBI.2005.11.002 [retrieved on 2006-02-25]
- SHOOP W L ET AL: "Avermectins and milbemycins against Fasciola hepatica: In vivo drug
efficacy and in vitro receptor binding", INTERNATIONAL JOURNAL FOR PARASITOLOGY, vol.
25, no. 8, 1995, pages 923-927, XP002671288, ISSN: 0020-7519
- MÁRTON JANI ET AL: "Ivermectin interacts with human ABCG2", JOURNAL OF PHARMACEUTICAL
SCIENCES, vol. 100, no. 1, 1 January 2011 (2011-01-01), pages 94-97, XP055021665,
ISSN: 0022-3549, DOI: 10.1002/jps.22262
- FISHER M H ET AL: "The chemistry and pharmacology of avermectins.", ANNUAL REVIEW
OF PHARMACOLOGY AND TOXICOLOGY 1992, vol. 32, 1992, pages 537-553, XP002688274, ISSN:
0362-1642
- ASIO S M ET AL: "A randomised, double-blind field trial of ivermectin alone and in
combination with albendazole for the treatment of Mansonella perstans infections in
Uganda", TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, ELSEVIER,
GB, vol. 103, no. 3, 1 March 2009 (2009-03-01) , pages 274-279, XP025917968, ISSN:
0035-9203, DOI: 10.1016/J.TRSTMH.2008.10.038 [retrieved on 2008-12-09]
- TOWNSON S ET AL: "The effects of ivermectin used in combination with other known antiparasitic
drugs on adult Onchocerca gutturosa and O. volvulus in vitro", TRANSACTIONS OF THE
ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, ELSEVIER, GB, vol. 84, no. 3, 1 May
1990 (1990-05-01), pages 411-416, XP023100877, ISSN: 0035-9203, DOI: 10.1016/0035-9203(90)90340-K
[retrieved on 1990-05-01]
- FURUSAWA SHINOBU ET AL: "Potentiation of doxorubicin-induced apoptosis of resistant
mouse leukaemia cells by ivermectin", PHARMACY AND PHARMACOLOGY COMMUNICATIONS, LONDON,
GB, vol. 6, no. 3, 1 March 2000 (2000-03-01), pages 129-134, XP009167795, ISSN: 1460-8081,
DOI: 10.1211/146080800128735764 [retrieved on 2010-02-18]
- SHENG-SHUNG PONG ET AL: "Studies on the Mechanism of Action of Avermectin B 1 a: Stimulation
of Release of ?-Aminobutyric Acid from Brain Synaptosomes", JOURNAL OF NEUROCHEMISTRY,
vol. 34, no. 2, 1 February 1980 (1980-02-01), pages 351-358, XP055060890, ISSN: 0022-3042,
DOI: 10.1111/j.1471-4159.1980.tb06604.x
- KOTZE A C: "Effects of macrocyclic lactones on ingestion in susceptible and resistant
Haemonchus contortus larvae", THE JOURNAL OF PARASITOLOGY, AMERICAN SOCIETY OF PARASITOLOGISTS,
US, vol. 84, no. 3, 1 June 1998 (1998-06-01), pages 631-635, XP008090959, ISSN: 0022-3395,
DOI: 10.2307/3284740
- DAWSON GERARD R ET AL: "Anticonvulsant and adverse effects of avermectin analogs in
mice are mediated through the gamma-aminobutyric acidA receptor", JOURNAL OF PHARMACOLOGY
AND EXPERIMENTAL THERAPEUTICS, vol. 295, no. 3, December 2000 (2000-12), pages 1051-1060,
XP002696207, ISSN: 0022-3565
- DENG Y ET AL: "House fly head GABA-gated chloride channel: Toxicologically relevant
binding site for avermectins coupled to site for ethynylbicycloorthobenzoate", PESTICIDE
BIOCHEMISTRY AND PHYSIOLOGY, ACADEMIC PRESS, US, vol. 43, no. 2, 1 June 1992 (1992-06-01),
pages 116-122, XP024866990, ISSN: 0048-3575, DOI: 10.1016/0048-3575(92)90025-U [retrieved
on 1992-06-01]
- SHOOP W L ET AL: "Efficacy in sheep and pharmacokinetics in cattle that led to the
selection of Eprinomectin as a topical endectocide for cattle", INTERNATIONAL JOURNAL
OF PARASITOLOGY, PERGAMON PRESS, GB, vol. 26, no. 11, 1 January 1996 (1996-01-01),
pages 1227-1235, XP002280645, ISSN: 0020-7519, DOI: 10.1016/S0020-7519(96)00122-1
- DENHAM D A: "THE EFFECTS OF SOME AVERMECTINS ON THE GROWTH OF BRUGIA-PAHANGI", METHODS
AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY, vol. 4, no. 5, 1982, pages
347-350, XP009169185, ISSN: 0379-0355
- BANKS B J ET AL: "Avermectins and flea control: structure-activity relationships and
the selection of selamectin for development as an endectocide for companion animals",
BIOORGANIC & MEDICINAL CHEMISTRY, PERGAMON, GB, vol. 8, no. 8, 1 August 2000 (2000-08-01),
pages 2017-2025, XP027414349, ISSN: 0968-0896 [retrieved on 2000-08-01]
- MICHAEL BRUCE ET AL: "Comparison of ivermectin, doramectin, selamectin, and eleven
intermediates in a nematode larval development assay", THE JOURNAL OF PARASITOLOGY,
AMERICAN SOCIETY OF PARASITOLOGISTS, US, vol. 87, no. 3, 1 June 2001 (2001-06-01),
pages 692-696, XP009169206, ISSN: 0022-3395
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