(19)
(11) EP 2 768 514 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
19.06.2019 Bulletin 2019/25

(45) Mention of the grant of the patent:
01.05.2019 Bulletin 2019/18

(21) Application number: 12841245.9

(22) Date of filing: 19.10.2012
(51) International Patent Classification (IPC): 
A61K 8/43(2006.01)
C07D 295/13(2006.01)
(86) International application number:
PCT/US2012/061205
(87) International publication number:
WO 2013/059735 (25.04.2013 Gazette 2013/17)

(54)

LOCALIZED MODULATION OF TISSUES AND CELLS TO ENHANCE THERAPEUTIC EFFECTS INCLUDING RENAL DENERVATION

LOKALISIERTE MODULATION VON GEWEBE UND ZELLEN ZUR VERBESSERUNG DER THERAPEUTISCHEN WIRKUNG EINSCHLIESSLICH NIERENDENERVIERUNG

MODULATION LOCALISÉE DE TISSUS ET DE CELLULES POUR AMÉLIORER DES EFFETS THÉRAPEUTIQUES COMPRENANT LA DÉNERVATION RÉNALE


(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

(30) Priority: 19.10.2011 US 201161548822 P

(43) Date of publication of application:
27.08.2014 Bulletin 2014/35

(60) Divisional application:
19164184.4

(73) Proprietor: Mercator Medsystems, Inc.
Emeryville, CA 94608 (US)

(72) Inventor:
  • SEWARD, Kirk, P.
    San Francisco, CA 94107 (US)

(74) Representative: MacLean, Martin Robert et al
Mathys & Squire LLP
The Shard 32 London Bridge Street London SE1 9SG
The Shard 32 London Bridge Street London SE1 9SG (GB)


(56) References cited: : 
WO-A1-2012/161875
US-A- 3 271 448
US-A- 3 723 463
US-A- 4 496 573
US-A1- 2011 104 061
US-B2- 7 022 214
WO-A2-01/43775
US-A- 3 301 755
US-A- 3 911 125
US-A- 6 009 875
US-B1- 6 787 569
US-B2- 7 074 834
   
  • DEMAS ET AL.: 'Novel method for localized, functional sympathetic nervous system denervation of peripheral tissue using guanethidine' JOURNAL OF NEUROSCIENCE METHODS vol. 112, no. 1, 2001, pages 21 - 28, XP055037343
  • WAHBI, ABDEL-AZIZ M. ET AL.: 'Spectrofluorimetric determination of guanethidine sulphate, guanfacine hydrochloride, guanoclor sulphate and guanoxan sulphate in tablets and biological fluids, using benzoin' MICROCHIMICA ACTA vol. 111, 1993, pages 83 - 91, XP005506628
   
Note: Within nine months from the publication of the mention of the grant of the European patent, any person may give notice to the European Patent Office of opposition to the European patent granted. Notice of opposition shall be filed in a written reasoned statement. It shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1) European Patent Convention).