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(11)

EP 2 771 069 A2

(12)

(88) Date of publication A3: 20.06.2013 (43) Date of publication: 03.09.2014 Bulletin 2014/36 (21) Application number: 12844282.9 (22) Date of filing: 26.10.2012

(51) International Patent Classification (IPC):  A61P 29/00(2006.01) A61P 37/00(2006.01) C07D 285/135(2006.01) C07D 403/10(2006.01) A61K 31/4196(2006.01) A61K 31/454(2006.01) A61K 31/497(2006.01) A61K 31/5377(2006.01) A61P 35/00(2006.01) C07D 249/12(2006.01) C07D 401/10(2006.01) C07D 413/10(2006.01) A61K 31/433(2006.01) A61K 31/496(2006.01) A61K 31/506(2006.01) (86) International application number: PCT/US2012/062206 (87) International publication number: WO 2013/063458 (02.05.2013 Gazette 2013/18)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR (30) Priority: 27.10.2011 US 201161552015 P (71) Applicant: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH Rochester, MN 55905 (US)	(72) Inventors: STEWART, Alexander Keith Scottsdale, Arizona 85259 (US) PLEKHOV, Artem Fremont, California 94539 (US) GREENHOUSE, Robert Newark, California 94560 (US) (74) Representative: Grund, Martin  Grund Intellectual Property Group Postfach 44 05 16 80754 München 80754 München (DE)