(19)

(11)

EP 2 776 051 A1

(12)

(43) Date of publication: 17.09.2014 Bulletin 2014/38 (21) Application number: 12842985.9 (22) Date of filing: 24.10.2012

(51) International Patent Classification (IPC):  A61K 38/00(2006.01) A61P 35/00(2006.01) A61K 39/395(2006.01) (86) International application number: PCT/US2012/061533 (87) International publication number: WO 2013/063001 (02.05.2013 Gazette 2013/18)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR (30) Priority: 28.10.2011 US 201161552893 P 02.08.2012 US 201261678978 P (71) Applicant: F.Hoffmann-La Roche AG 4070 Basel (CH)	(72) Inventors: POLAKIS, Paul South San Francisco, California 94080 (US) ASUNDI, Jyoti South San Francisco, California 94080 (US) CLARK, Suzanna Pacifica, California 94080 (US) (74) Representative: Brodbeck, Michel et al F. Hoffmann-La Roche AG Patent Department Grenzacherstrasse 124 4070 Basel 4070 Basel (CH)