(19)
(11) EP 2 776 399 A1

(12)

(43) Date of publication:
17.09.2014 Bulletin 2014/38

(21) Application number: 12781341.8

(22) Date of filing: 08.11.2012
(51) International Patent Classification (IPC): 
C07D 231/12(2006.01)
A61P 29/00(2006.01)
 A61K 31/415(2006.01)
(86) International application number:
PCT/EP2012/072141
(87) International publication number:
WO 2013/068462 (16.05.2013 Gazette 2013/20)
(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

(30) Priority: 09.11.2011 EP 11008913

(71) Applicant: Grünenthal GmbH
52078 Aachen (DE)

(72) Inventors:
  • FRANK-FOLTYN, Robert
    52070 Aachen (DE)
  • CHRISTOPH, Thomas
    52080 Aachen (DE)
  • DAMANN, Nils
    50939 Köln (DE)
  • LESCH, Bernhard
    52076 Aachen (DE)
  • BAHRENBERG, Gregor
    52156 Monschau-Konzen (DE)
  • SAUNDERS, Derek John
    52072 Aachen (DE)
  • STOCKHAUSEN, Hannelore
    52393 Hürtgenwald (DE)
  • KIM, Yong-Soo
    Yangsan Gyengnam (KR)
  • KIM, Myeong-Seop
    Yeongwol-gun Gangw-do (KR)
  • LEE, Jeewoo
    Seoul 151-742 (KR)

(74) Representative: Brosch, Oliver et al
Kutzenberger Wolff & Partner Theodor-Heuss-Ring 23
50668 Köln
50668 Köln (DE)

   


(54) SUBSTITUTED PYRAZOLYL-BASED CARBOXAMIDE AND UREA DERIVATIVES BEARING A PHENYL MOIETY SUBSTITUTED WITH AN N-CONTAINING GROUP AS VANILLOID RECEPTOR LIGANDS