(19)

(11)

EP 2 788 381 A2

(12)

(88) Date of publication A3: 03.01.2014 (43) Date of publication: 15.10.2014 Bulletin 2014/42 (21) Application number: 12816130.4 (22) Date of filing: 04.12.2012

(51) International Patent Classification (IPC):  C07K 16/32(2006.01) (86) International application number: PCT/IB2012/056956 (87) International publication number: WO 2013/084151 (13.06.2013 Gazette 2013/24)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR (30) Priority: 05.12.2011 US 201161566912 P (71) Applicant: Novartis AG 4056 Basel (CH)

(72) Inventors: ELIS, Winfried 82152 Planegg (DE) ETTENBERG, Seth Cambridge, MA 02139 (US) GARNER, Andrew, Paul Cambridge, MA 02139 (US) HAUBST, Nicole 82152 Planegg (DE) HUET, Heather Cambridge, MA 02139 (US) KUNZ, Christian, Carsten, Silvester 82152 Planegg (DE) REISINGER SPRAGUE, Elizabeth, Anne Cambridge, MA 02139 (US) SHENG, Qing Cambridge, MA 02139 (US) (74) Representative: Gill-Carey, Daniela  Novartis Pharma AG Patent Department 4002 Basel 4002 Basel (CH)