(19)

(11)

EP 2 788 490 A1

(12)

(43) Date of publication: 15.10.2014 Bulletin 2014/42 (21) Application number: 12854779.1 (22) Date of filing: 04.12.2012

(51) International Patent Classification (IPC):  C12N 15/40(2006.01) C12Q 1/68(2006.01) A61K 39/12(2006.01) (86) International application number: PCT/US2012/067731 (87) International publication number: WO 2013/085889 (13.06.2013 Gazette 2013/24)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR (30) Priority: 05.12.2011 US 201161630161 P (71) Applicant: Duke University Durham, NC 27705 (US)	(72) Inventors: SHAW, George M. Wallingford, PA 19086-6047 (US) LI, Hui Ardmore, PA 19003 (US) HAHN, Beatrice H. Wallingford, PA 19086-6047 (US) HAYNES, Barton F. Durham, NC 27707 (US) (74) Representative: Atkinson, Peter Birch  Marks & Clerk LLP 1 New York Street Manchester, M1 4HD Manchester, M1 4HD (GB)