(19)
(11) EP 2 805 963 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
02.08.2017 Bulletin 2017/31

(45) Mention of the grant of the patent:
12.04.2017 Bulletin 2017/15

(21) Application number: 13738569.6

(22) Date of filing: 16.01.2013
(51) International Patent Classification (IPC): 
C07K 14/00(2006.01)
A61P 25/28(2006.01)
C07K 7/06(2006.01)
 A61K 38/55(2006.01)
A61P 43/00(2006.01)
(86) International application number:
PCT/JP2013/050663
(87) International publication number:
WO 2013/108780 (25.07.2013 Gazette 2013/30)

(54)

AMYLOID BETA-PROTEIN-SPECIFIC PRODUCTION-INHIBITING POLYPEPTIDE

POLYPEPTID ZUR HEMMUNG EINER BETA AMYLOIDPROTEINSPEZIFISCHEN PRODUKTION

POLYPEPTIDE POUR L'INHIBITION DE LA PRODUCTION SPÉCIFIQUE DE PROTÉINE AMYLOÏDE BETA

(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

(30) Priority: 17.01.2012 JP 2012006687
21.09.2012 JP 2012208277

(43) Date of publication of application:
26.11.2014 Bulletin 2014/48

(73) Proprietor: The Doshisha
Kyoto 602-8580 (JP)

(72) Inventors:
  • IHARA, Yasuo
    Kyotanabe-shi Kyoto 610-0394 (JP)
  • FUNAMOTO, Satoru
    Kyotanabe-shi Kyoto 610-0394 (JP)
  • SASAKI, Toru
    Tokyo 153-8904 (JP)

(74) Representative: Marks & Clerk (Luxembourg) LLP 
44, rue de la Vallée
2661 Luxembourg
2661 Luxembourg (LU)


(56) References cited: : 
WO-A1-2009/068269
US-A1- 2009 176 711
 WO-A1-2009/068269
   
  • SANJIV SHAH ET AL: "Nicastrin Functions as a [gamma]-Secretase-Substrate Receptor", CELL, vol. 122, no. 3, 1 August 2005 (2005-08-01), pages 435-447, XP055078309, ISSN: 0092-8674, DOI: 10.1016/j.cell.2005.05.022
  • MILES ET AL: "Amyloid-beta-Anti-Amyloid-beta Complex Structure Reveals an Extended Conformation in the Immunodominant B-Cell Epitope", JOURNAL OF MOLECULAR BIOLOGY, ACADEMIC PRESS, UNITED KINGDOM, vol. 377, no. 1, 30 January 2008 (2008-01-30), pages 181-192, XP022501452, ISSN: 0022-2836, DOI: 10.1016/J.JMB.2007.12.036
  • FUNAMOTO SATORU ET AL: "Substrate ectodomain is critical for substrate preference and inhibition of [gamma]-secretase.", NATURE COMMUNICATIONS 2013, vol. 4, 2013, page 2529, XP002740200, ISSN: 2041-1723
  • SHAH S. ET AL.: 'Nicastrin Functions as a gammma-Secretase-Substrate Receptor' CELL vol. 122, 2005, pages 435 - 447, XP055078309
   
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