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EP 2 814 834 A1

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(43) Date of publication: 24.12.2014 Bulletin 2014/52 (21) Application number: 13707493.6 (22) Date of filing: 13.02.2013

(51) International Patent Classification (IPC):  C07J 63/00(2006.01) A61K 31/575(2006.01) A61K 31/58(2006.01) A61P 31/18(2006.01) (86) International application number: PCT/US2013/025897 (87) International publication number: WO 2013/123019 (22.08.2013 Gazette 2013/34)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME (30) Priority: 15.02.2012 US 201261599040 P 06.02.2013 US 201313760726 (71) Applicant: Bristol-Myers Squibb Company Princeton, NJ 08543 (US)

(72) Inventors: SWIDORSKI, Jacob Wallingford, Connecticut 06492 (US) MEANWELL, Nicholas A. Wallingford, Connecticut 06492 (US) REGUEIRO-REN, Alicia Wallingford, Connecticut 06492 (US) SIT, Sing-Yuen Wallingford, Connecticut 06492 (US) CHEN, Jie Wallingford, Connecticut 06492 (US) CHEN, Yan Wallingford, Connecticut 06492 (US) (74) Representative: Reitstötter Kinzebach  Patentanwälte Sternwartstrasse 4 81679 München 81679 München (DE)