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EP 2 819 680 A1

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(43) Date of publication: 07.01.2015 Bulletin 2015/02 (21) Application number: 12718446.3 (22) Date of filing: 28.02.2012

(51) International Patent Classification (IPC):  A61K 31/704(2006.01) A61P 35/00(2006.01) A61K 35/00(2006.01) (86) International application number: PCT/US2012/026986 (87) International publication number: WO 2013/130049 (06.09.2013 Gazette 2013/36)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME (71) Applicant: Maine Institute For Human Genetics And Health Brewer, ME 04412 (US)	(72) Inventor: HOELZ, Derek J. Bangor, ME 04401 (US) (74) Representative: Hiebl, Inge Elisabeth  Kraus & Weisert Patentanwälte PartGmbB Thomas-Wimmer-Ring 15 80539 München 80539 München (DE)