(19)

(11)

EP 2 822 379 A1

(12)

(43) Date of publication: 14.01.2015 Bulletin 2015/03 (21) Application number: 13712618.1 (22) Date of filing: 05.03.2013

(51) International Patent Classification (IPC):  A01K 67/027(2006.01) C07K 16/00(2006.01) C12N 15/85(2006.01) (86) International application number: PCT/US2013/029125 (87) International publication number: WO 2013/134263 (12.09.2013 Gazette 2013/37)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME (30) Priority: 06.03.2012 US 201213412936 (71) Applicant: Regeneron Pharmaceuticals, Inc. Tarrytown, NY 10591 (US)

(72) Inventors: BABB, Robert River Edge, NJ 07661 (US) McWHIRTER, John Tarrytown, NY 10591 (US) MACDONALD, Lynn White Plains, NY 10505 (US) STEVENS, Sean San Francisco, CA 94158 (US) DAVIS, Samuel New York, NY 10024 (US) BUCKLER, David, R. Chester, NJ 07930 (US) MEAGHER, Karolina, A. Tarrytown, NY 10591 (US) MURPHY, Andrew, J. Croton-on-Hudson, NY 10520 (US) (74) Representative: Power, David  J A Kemp 14 South Square Gray's Inn London WC1R 5JJ London WC1R 5JJ (GB)