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(11)

EP 2 825 693 A1

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(43) Date of publication: 21.01.2015 Bulletin 2015/04 (21) Application number: 13760532.5 (22) Date of filing: 15.03.2013

(51) International Patent Classification (IPC):  C40B 20/00(2006.01) A61K 31/7088(2006.01) C40B 40/08(2006.01) A61P 35/00(2006.01) (86) International application number: PCT/US2013/031953 (87) International publication number: WO 2013/138697 (19.09.2013 Gazette 2013/38)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME (30) Priority: 15.03.2012 US 201261611387 P (71) Applicants: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH Rochester, MN 55905 (US) University of Leeds Leeds, Yorkshire LS2 9JT (GB)	(72) Inventors: MELCHER, Alan Roundhay Leeds LS8 1JE (GB) SELBY, Peter Roundhay Leeds LS8 2EX (GB) PULIDO, Jose S. Rochester, MN 55902 (US) VILE, Richard G. Rochester, MN 55902 (US) KOTTKE, Timothy J. Oronoco, MN 55960 (US) (74) Representative: Grund, Martin  Grund Intellectual Property Group Postfach 44 05 16 80754 München 80754 München (DE)