(19)

(11)

EP 2 830 604 A1

(12)

(43) Date of publication: 04.02.2015 Bulletin 2015/06 (21) Application number: 13767616.9 (22) Date of filing: 29.03.2013

(51) International Patent Classification (IPC):  A61K 31/135(2006.01) A61P 25/24(2006.01) A61K 36/81(2006.01) (86) International application number: PCT/US2013/034524 (87) International publication number: WO 2013/149102 (03.10.2013 Gazette 2013/40)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME (30) Priority: 30.03.2012 US 201261618212 P (71) Applicant: The General Hospital Corporation Boston, MA 02114 (US)	(72) Inventors: FAVA, Maurizio Newton, MA 02460 (US) PETRYSHEN, Tracey Arlington, MA 02474 (US) (74) Representative: Griffin, Philippa Jane  Mathys & Squire LLP The Shard 32 London Bridge Street London SE1 9SG London SE1 9SG (GB)