| (84) |
Designated Contracting States: |
|
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL
NO PL PT RO RS SE SI SK SM TR |
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Designated Extension States: |
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BA ME |
| (30) |
Priority: |
26.03.2012 US 201261615629 P
14.03.2013 US 201313830494
|
| (43) |
Date of publication of application: |
|
04.02.2015 Bulletin 2015/06 |
| (60) |
Divisional application: |
|
17165825.5 / 3263701 |
| (73) |
Proprietor: The Regents of the University of Colorado, a body
corporate |
|
Denver, CO 80203 (US) |
|
| (72) |
Inventors: |
|
- CARRILLO, Richard, G.
Oakland, CA 94609 (US)
- KRAUS, Jan, P.
Littleton, CO 80123 (US)
- MAJTAN, Tomas
Aurora, CO 80011 (US)
- NAVEH, David
Piedmont, CA 94611 (US)
|
| (74) |
Representative: Rees, Kerry et al |
|
WP Thompson
138 Fetter Lane
London EC4A 1BT
London EC4A 1BT (GB) |
| (56) |
References cited: :
EP-A1- 1 396 537
WO-A1-95/07714
WO-A2-2011/097381
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EP-A1- 1 878 739
WO-A2-03/106971
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- BELEW M S ET AL: "Kinetic characterization of recombinant human cystathionine beta-synthase
purified from E. coli", PROTEIN EXPRESSION AND PURIFICATION, ACADEMIC PRESS, SAN DIEGO,
CA, vol. 64, no. 2, 1 April 2009 (2009-04-01), pages 139-145, XP025924316, ISSN: 1046-5928,
DOI: 10.1016/J.PEP.2008.10.012 [retrieved on 2008-10-30]
- FRANK ET AL: "Purification and characterization of the wild type and truncated human
cystathionine beta-synthase enzymes expressed in E. coli", ARCHIVES OF BIOCHEMISTRY
AND BIOPHYSICS, ACADEMIC PRESS, US, vol. 470, no. 1, 17 November 2007 (2007-11-17),
pages 64-72, XP022424131, ISSN: 0003-9861, DOI: 10.1016/J.ABB.2007.11.006
- ROMAN VOZDEK ET AL: "Novel structural arrangement of nematode cystathionine [beta]-synthases:
characterization of Caenorhabditis elegans CBS-1", BIOCHEMICAL JOURNAL, vol. 16, no.
2, 15 April 2012 (2012-04-15) , pages 1066-547, XP055066236, ISSN: 0264-6021, DOI:
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