(19)
(11) EP 2 831 526 A1

(12)

(43) Date of publication:
04.02.2015 Bulletin 2015/06

(21) Application number: 12716817.7

(22) Date of filing: 28.03.2012
(51) International Patent Classification (IPC): 
F26B 5/06(2006.01)
(86) International application number:
PCT/US2012/030854
(87) International publication number:
WO 2013/147759 (03.10.2013 Gazette 2013/40)
(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated Extension States:
BA ME

(71) Applicants:
  • Baxter International Inc
    Deerfield, IL 60015 (US)
  • Baxter Healthcare SA
    8152 Glattpark (Opfikon) (CH)

(72) Inventors:
  • KUU, Wei-Youh
    Libertyville, IL 60048 (US)
  • DOTY, Mark, J.
    Grayslake, IL 60030 (US)
  • HURST, William, S.
    Burlington, WI 53105-7781 (US)
  • REBBECK, Christine, L.
    Algonquin, IL 60102 (US)

(74) Representative: Potter Clarkson LLP 
The Belgrave Centre Talbot Street
Nottingham, NG1 5GG
Nottingham, NG1 5GG (GB)

   


(54) OPTIMIZATION OF NUCLEATION AND CRYSTALLIZATION FOR LYOPHILIZATION USING GAP FREEZING