(19)

(11)

EP 2 841 444 A1

(12)

(43) Date of publication: 04.03.2015 Bulletin 2015/10 (21) Application number: 13780667.5 (22) Date of filing: 22.04.2013

(51) International Patent Classification (IPC):  C07J 43/00(2006.01) C07J 75/00(2006.01) A61K 31/58(2006.01) C07J 9/00(2006.01) (86) International application number: PCT/CA2013/050311 (87) International publication number: WO 2013/159225 (31.10.2013 Gazette 2013/44)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME (30) Priority: 23.04.2012 US 201261637048 P 03.05.2012 US 201261642253 P (71) Applicant: Alphora Research Inc. Mississauga, Ontario L5K 1B3 (CA)	(72) Inventors: DIXON, Craig E. Brooklin, Ontario L1M 0G7 (CA) LU, Qingbo Mississauga, Ontario L5M 7W4 (CA) GORIN, Boris Oakville, Ontario L6H 6A8 (CA) SCHREINER, Erwin A-1230 Vienna (AT) (74) Representative: Hally, Anna-Louise  FRKelly 27 Clyde Road Dublin 4 Dublin 4 (IE)