(19)

(11)

EP 2 841 588 A2

(12)

(88) Date of publication A3: 06.03.2014 (43) Date of publication: 04.03.2015 Bulletin 2015/10 (21) Application number: 13725503.0 (22) Date of filing: 26.04.2013

(51) International Patent Classification (IPC):  C12P 19/02(2006.01) C12P 7/10(2006.01) D21C 1/10(2006.01) C12P 19/14(2006.01) D21C 1/06(2006.01) (86) International application number: PCT/US2013/038452 (87) International publication number: WO 2013/163571 (31.10.2013 Gazette 2013/44)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME (30) Priority: 27.04.2012 US 201213458830 (71) Applicants: The Michigan Biotechnology Institute Lansing, Michigan 48910 (US) Board Of Trustees Of Michigan State University East Lansing, Michigan 48824-1046 (US)	(72) Inventors: BALS, Bryan East Lansing, Michigan 48823 (US) TEYMOURI, Farzaneh Okemos, Michigan 48864 (US) CAMPBELL, Timothy J. East Lansing, Michigan 48823 (US) DALE, Bruce E. Mason, Michigan 48854 (US) (74) Representative: LifeTech IP Spies Danner & Partner Patentanwälte PartG mbB  Elsenheimerstrasse 47a 80687 München 80687 München (DE)