(19)

(11)

EP 2 844 248 A1

(12)

(43) Date of publication: 11.03.2015 Bulletin 2015/11 (21) Application number: 13708841.5 (22) Date of filing: 13.03.2013

(51) International Patent Classification (IPC):  A61K 31/41(2006.01) A61P 35/00(2006.01) (86) International application number: PCT/EP2013/055085 (87) International publication number: WO 2013/135745 (19.09.2013 Gazette 2013/38)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME (30) Priority: 16.03.2012 US 201261612202 P (71) Applicant: F.Hoffmann-La Roche AG 4070 Basel (CH)	(72) Inventors: HOEFLICH, Klaus P. South San Francisco, California 94080 (US) JUBB, Adrian M. South San Francisco, California 94080 (US) KOEPPEN, Hartmut South San Francisco, California 94080 (US) ONG, Christy C. South San Francisco, California 94080 (US) (74) Representative: Schirlin, Julien  F. Hoffmann-La Roche AG CLP - Patent Department Grenzacherstrasse 124 4070 Basel 4070 Basel (CH)