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EP 2 844 301 A2

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(88) Date of publication A3: 09.01.2014 (43) Date of publication: 11.03.2015 Bulletin 2015/11 (21) Application number: 13722013.3 (22) Date of filing: 07.05.2013

(51) International Patent Classification (IPC):  A61K 47/48(2006.01) A61P 31/04(2006.01) A61P 1/04(2006.01) (86) International application number: PCT/GB2013/051181 (87) International publication number: WO 2013/164652 (07.11.2013 Gazette 2013/45)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME (30) Priority: 04.05.2012 US 201261642587 P (71) Applicants: Ineb-instituto de Engenharia Biomédica 4150-180 Porto (PT) IPATIMUP Institute of Molecular Pathology and Immunology of The University of Porto 4200-465 Porto (PT) Universidade Do Porto 4099-002 Porto (PT)

(72) Inventors: MARTINS, Cristina 4150-180 Porto (PT) GONÇALVES, Inês 4150-180 Porto (PT) GOMES, Paula 4169-007 Porto (PT) OLIVEIRA, José Ricardo 4169-007 Porto (PT) REIS, Celso 4200-465 Porto (PT) MAGALHÃES, Ana 4200-465 Porto (PT) (74) Representative: Teixeira de Carvalho, Anabela  Edificio Net Rua de Salazares 842 4149-002 Porto 4149-002 Porto (PT)