COMPOSITIONS AND METHODS FOR MODULATING GENE EXPRESSION

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EP 2 850 189 B8

(12)	CORRECTED EUROPEAN PATENT SPECIFICATION
	Note: Bibliography reflects the latest situation

(15)	Correction information:
	Corrected version no 1 (W1 B1)

(48)	Corrigendum issued on:
	23.01.2019 Bulletin 2019/04

(45)	Mention of the grant of the patent:
	07.11.2018 Bulletin 2018/45

(21)	Application number: 13791343.0

(22)	Date of filing: 16.05.2013

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International Patent Classification (IPC):

C12N 15/113^(2010.01)
A61K 48/00^(2006.01)

C12N 15/11^(2006.01)

(86)	International application number:
	PCT/US2013/041461

(87)	International publication number:
	WO 2013/173652 (21.11.2013 Gazette 2013/47)

(54)	COMPOSITIONS AND METHODS FOR MODULATING GENE EXPRESSION ZUSAMMENSETZUNGEN UND VERFAHREN ZUR MODULATION VON GENEXPRESSION COMPOSITIONS ET MÉTHODES POUR MODULER L'EXPRESSION GÉNIQUE

(84)	Designated Contracting States:
	AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

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Priority:

16.05.2012 US 201261647949 P
16.05.2012 US 201261648016 P
16.05.2012 US 201261648021 P
16.05.2012 US 201261647858 P
16.05.2012 US 201261647925 P
16.05.2012 US 201261647886 P
16.05.2012 US 201261647901 P
16.05.2012 US 201261648041 P
16.05.2012 US 201261648051 P
16.05.2012 US 201261648058 P
27.10.2012 US 201261719394 P
14.03.2013 US 201361785832 P
14.03.2013 US 201361785778 P
14.03.2013 US 201361785885 P
14.03.2013 US 201361786232 P
14.03.2013 US 201361785956 P
14.03.2013 US 201361785529 P

(43)	Date of publication of application:
	25.03.2015 Bulletin 2015/13

(60)	Divisional application:
	18204559.1

(73)	Proprietors:
	Translate Bio MA, Inc. Lexington, MA 02421 (US) The General Hospital Corporation Boston, MA 02114 (US)

(72)	Inventors:
	KRIEG, Arthur, M. Wellesley, MA 02482 (US) SUBRAMANIAN, Romesh Framingham, MA 01701 (US) MCSWIGGEN, James Arlington, MA 02474 (US) LEE, Jeannie, T. Boston, MA 02114 (US)

(74)	Representative: Hoffmann Eitle
	Patent- und Rechtsanwälte PartmbB Arabellastraße 30 81925 München 81925 München (DE)

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References cited: :

WO-A1-2012/065143
WO-A1-2012/087983
WO-A2-2007/131237
US-A1- 2011 251 261

WO-A1-2012/087983
WO-A2-2004/092356
WO-A2-2012/018881
US-A1- 2012 004 278

JING ZHAO ET AL: "Genome-wide Identification of Polycomb-Associated RNAs by RIP-seq", MOLECULAR CELL., vol. 40, no. 6, 1 December 2010 (2010-12-01), pages 939-953, XP055232287, US ISSN: 1097-2765, DOI: 10.1016/j.molcel.2010.12.011
A. M. KHALIL ET AL: "Many human large intergenic noncoding RNAs associate with chromatin-modifying complexes and affect gene expression", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, vol. 106, no. 28, 14 July 2009 (2009-07-14), pages 11667-11672, XP55073351, ISSN: 0027-8424, DOI: 10.1073/pnas.0904715106
WANG, YU ET AL.: 'Long non-coding RNA UCAla(CUDR) promotes proliferation and tumorigenesis of bladder cancer' INT. J. ONCOL. vol. 41, no. 1, 20 April 2012, pages 276 - 284, XP055177810
NYCE JW LI Y SANDRASAGRA A KATZ E PABALAN J AGUILAR D ET AL: "Human oligonucleotide sequence", GENESEQ,, 31 October 2002 (2002-10-31), XP002751891, [retrieved on 2003-10-17]

Note: Within nine months from the publication of the mention of the grant of the European patent, any person may give notice to the European Patent Office of opposition to the European patent granted. Notice of opposition shall be filed in a written reasoned statement. It shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1) European Patent Convention).