(19)
(11) EP 2 855 665 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
25.09.2019 Bulletin 2019/39

(45) Mention of the grant of the patent:
31.07.2019 Bulletin 2019/31

(21) Application number: 13797778.1

(22) Date of filing: 30.05.2013
(51) International Patent Classification (IPC): 
C12N 5/0735(2010.01)
C12N 5/10(2006.01)
A61K 48/00(2006.01)
A61K 35/44(2015.01)
 C12N 15/63(2006.01)
A61P 35/00(2006.01)
A61K 35/12(2015.01)
C12N 5/071(2010.01)
(86) International application number:
PCT/US2013/043236
(87) International publication number:
WO 2013/181326 (05.12.2013 Gazette 2013/49)

(54)

GENERATION OF FUNCTIONAL AND DURABLE ENDOTHELIAL CELLS FROM HUMAN AMNIOTIC FLUID-DERIVED CELLS

ERZEUGUNG VON FUNKTIONELLEN UND BESTÄNDIGEN ENDOTHELZELLEN AUS ZELLEN AUS MENSCHLICHER AMNIOTISCHER FLÜSSIGKEIT

GÉNÉRATION DE CELLULES ENDOTHÉLIALES FONCTIONNELLES ET DURABLES À PARTIR DE CELLULES DÉRIVÉES DU FLUIDE AMNIOTIQUE HUMAIN

(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

(30) Priority: 30.05.2012 US 201261653185 P
04.10.2012 US 201261709431 P

(43) Date of publication of application:
08.04.2015 Bulletin 2015/15

(73) Proprietor: Cornell University
Ithaca, NY14850 (US)

(72) Inventors:
  • RAFII, Shahin
    Great Neck, NY 10021 (US)
  • RABBANY, Sina Y.
    Great Neck, NY 11021 (US)
  • GINSBERG, Michael
    New York, NY 10065 (US)

(74) Representative: Roberts, Michael Austin 
Reddie & Grose LLP The White Chapel Building 10 Whitechapel High Street
London E1 8QS
London E1 8QS (GB)


(56) References cited: : 
WO-A2-2008/089448
WO-A2-2012/006440
US-A1- 2012 009 618
 WO-A2-2011/090684
WO-A2-2012/064834
   
  • PING ZHANG ET AL: "Endothelial Differentiation of Amniotic Fluid-Derived Stem Cells: Synergism of Biochemical and Shear Force Stimuli", STEM CELLS AND DEVELOPMENT, vol. 18, no. 9, 1 November 2009 (2009-11-01), pages 1299-1308, XP055095267, ISSN: 1547-3287, DOI: 10.1089/scd.2008.0331
  • OMAR M. BENAVIDES ET AL: "Evaluation of Endothelial Cells Differentiated from Amniotic Fluid-Derived Stem Cells", TISSUE ENGINEERING PART A, vol. 18, no. 11-12, 9 March 2012 (2012-03-09), pages 1123-1131, XP055216124, ISSN: 1937-3341, DOI: 10.1089/ten.tea.2011.0392
  • DAYLON JAMES ET AL: "Expansion and maintenance of human embryonic stem cell-derived endothelial cells by TGF beta inhibition is Id1 dependent", NATURE BIOTECHNOLOGY, NATURE PUBLISHING GROUP, US, [Online] vol. 28, no. 2, 1 February 2010 (2010-02-01), pages 161-166,1, XP002682519, ISSN: 1087-0156, DOI: 10.1038/NBT.1605 Retrieved from the Internet: URL:http://www.nature.com/nbt/journal/v28/ n2/full/nbt.1605.html> [retrieved on 2010-01-17]
  • STRYDER M. MEADOWS ET AL: "Regulation of endothelial cell development by ETS transcription factors", SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, vol. 22, no. 9, 1 December 2011 (2011-12-01), pages 976-984, XP055216004, ISSN: 1084-9521, DOI: 10.1016/j.semcdb.2011.09.009
  • H. KATAOKA ET AL: "Etv2/ER71 induces vascular mesoderm from Flk1+PDGFR + primitive mesoderm", BLOOD, vol. 118, no. 26, 22 December 2011 (2011-12-22), pages 6975-6986, XP055216030, ISSN: 0006-4971, DOI: 10.1182/blood-2011-05-352658
   
Note: Within nine months from the publication of the mention of the grant of the European patent, any person may give notice to the European Patent Office of opposition to the European patent granted. Notice of opposition shall be filed in a written reasoned statement. It shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1) European Patent Convention).