COMPOSITIONS AND METHODS FOR SILENCING GENE EXPRESSION

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EP 2 855 680 B8

(12)	CORRECTED EUROPEAN PATENT SPECIFICATION
	Note: Bibliography reflects the latest situation

(15)	Correction information:
	Corrected version no 1 (W1 B1)

(48)	Corrigendum issued on:
	15.04.2020 Bulletin 2020/16

(45)	Mention of the grant of the patent:
	26.02.2020 Bulletin 2020/09

(21)	Application number: 13794339.5

(22)	Date of filing: 23.05.2013

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International Patent Classification (IPC):

C12N 15/82^(2006.01)
A01N 63/02^(2006.01)

A01H 3/04^(2006.01)
A01H 5/10^(2018.01)

(86)	International application number:
	PCT/IL2013/050447

(87)	International publication number:
	WO 2013/175480 (28.11.2013 Gazette 2013/48)

(54)	COMPOSITIONS AND METHODS FOR SILENCING GENE EXPRESSION ZUSAMMENSETZUNGEN UND VERFAHREN ZUR AUSSCHALTUNG EINER GENEXPRESSION COMPOSITIONS ET PROCÉDÉS POUR LE SILENÇAGE DE L'EXPRESSION GÉNIQUE

(84)	Designated Contracting States:
	AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

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Priority:

24.05.2012 US 201261651131 P
23.04.2013 US 201361814888 P
23.04.2013 US 201361814892 P
23.04.2013 US 201361814899 P
23.04.2013 US 201361814890 P

(43)	Date of publication of application:
	08.04.2015 Bulletin 2015/15

(73)	Proprietor: Monsanto Technology LLC
	St. Louis, MO 63167 (US)

(72)	Inventors:
	AVNIEL, Amir 6219207 Tel-Aviv (IL) LIDOR-NILI, Efrat 7405492 Nes Ziona (IL) MAOR, Rudy 7666206 Rechovot (IL) MEIR, Ofir 7688500 Doar-Na Emek Soreq (IL) NOIVIRT-BRIK, Orly 5339711 Givataim (IL) YANAI-AZULAY, Osnat 7543571 Rishon-LeZion (IL)

(74)	Representative: Dennemeyer & Associates S.A.
	Postfach 70 04 25 81304 München 81304 München (DE)

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References cited: :

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WO-A1-2006/138638
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US-A1- 2012 107 355

WO-A1-99/32619
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WO-A2-2014/106837
US-A1- 2004 126 845
US-A1- 2007 011 775
US-A1- 2010 071 088
US-B1- 6 992 237

KLAHRE U ET AL: "High molecular weight RNAs and small interfering RNAs induce systemic posttranscriptional gene silencing in plants", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, NATIONAL ACADEMY OF SCIENCES, US, vol. 99, no. 18, 3 September 2002 (2002-09-03), pages 11981-11986, XP002248496, ISSN: 0027-8424, DOI: 10.1073/PNAS.182204199
UNNAMALAI N ET AL: "Cationic oligopeptide-mediated delivery of dsRNA for post-transcriptional gene silencing in plant cells", FEBS LETTERS, ELSEVIER, AMSTERDAM, NL, vol. 566, no. 1-3, 21 May 2004 (2004-05-21), pages 307-310, XP004509368, ISSN: 0014-5793, DOI: 10.1016/J.FEBSLET.2004.04.018
KLAHRE ET AL.: 'High molecular weight RNAs and small interfering RNAs induce systemic posttranscriptional gene silencing in plants.' PROC NATL ACAD SCI U S A. vol. 99, no. 18, 03 September 2002, pages 11981 - 11986, XP002248496
DALMAY ET AL.: 'An RNA-dependent RNA polymerase gene in Arabidopsis is required for posttranscriptional gene silencing mediated by a transgene but not by a virus.' CELL vol. 101, no. 5, 26 May 2000, pages 543 - 53, XP002149067

Note: Within nine months from the publication of the mention of the grant of the European patent, any person may give notice to the European Patent Office of opposition to the European patent granted. Notice of opposition shall be filed in a written reasoned statement. It shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1) European Patent Convention).