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(11)

EP 2 858 636 A1

(12)

(43) Date of publication: 15.04.2015 Bulletin 2015/16 (21) Application number: 13800873.5 (22) Date of filing: 07.06.2013

(51) International Patent Classification (IPC):  A61K 31/165(2006.01) A61K 31/382(2006.01) A61K 31/195(2006.01) A61K 9/48(2006.01) (86) International application number: PCT/US2013/044828 (87) International publication number: WO 2013/185105 (12.12.2013 Gazette 2013/50)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME (30) Priority: 07.06.2012 US 201261656815 P (71) Applicant: Childrens Hospital Los Angeles Los Angeles, CA 90027 (US)	(72) Inventor: WU, Lingtao Rancho Palos Verdes, California 90275 (US) (74) Representative: Care, Alison et al Kilburn & Strode LLP 20 Red Lion Street London WC1R 4PJ London WC1R 4PJ (GB)