(19)

(11)

EP 2 858 644 A1

(12)

(43) Date of publication: 15.04.2015 Bulletin 2015/16 (21) Application number: 12740116.4 (22) Date of filing: 18.07.2012

(51) International Patent Classification (IPC):  A61K 31/401(2006.01) A61P 31/04(2006.01) (86) International application number: PCT/EP2012/064096 (87) International publication number: WO 2013/182254 (12.12.2013 Gazette 2013/50)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME (30) Priority: 06.06.2012 IT MI20120980 (71) Applicants: Fondazione Roma 00187 Roma (IT) Università degli Studi di Roma "La Sapienza" 00185 Roma (IT)	(72) Inventors: VALENTI, Piera I-00153 Roma (IT) NATALIZI, Tiziana I-00146 Roma (IT) DI SANTO, Roberto I-00121 Roma (IT) PESCATORI, Luca I-43044 Collecchio (IT) CUZZUCOLI CRUCITTI, Giuliana I-00132 Roma (IT) ILARI, Andrea I-00179 Roma (IT) CHIANCONE, Emilia I-00197 Roma (IT) (74) Representative: Modiano, Micaela Nadia et al Modiano & Partners (IT) Via Meravigli, 16 20123 Milano 20123 Milano (IT)