| (84) |
Designated Contracting States: |
|
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL
NO PL PT RO RS SE SI SK SM TR |
| (30) |
Priority: |
08.06.2012 US 201261657574 P
|
| (43) |
Date of publication of application: |
|
15.04.2015 Bulletin 2015/16 |
| (73) |
Proprietors: |
|
- Aduro BioTech, Inc.
Berkeley, California 94710 (US)
- The Johns Hopkins University
Baltimore, Maryland 21218 (US)
|
|
| (72) |
Inventors: |
|
- DUBENSKY, Thomas, W.
Piedmont, CA 94611 (US)
- LEONG, Meredith, Lai Ling
Oakland, CA 94611 (US)
- PARDOLL, Drew, M.
Brookeville, MD 20833 (US)
- KIM, Young, Jun
Ellicott City, MD 21043 (US)
|
| (74) |
Representative: Brasnett, Adrian Hugh et al |
|
Mewburn Ellis LLP
City Tower
40 Basinghall Street
London EC2V 5DE
City Tower
40 Basinghall Street
London EC2V 5DE (GB) |
| (56) |
References cited: :
WO-A1-2011/136828
US-A- 5 637 483
US-A1- 2011 262 485
|
WO-A1-2014/093936
US-A1- 2007 281 897
|
|
| |
|
|
- Woodward et al.: "supporting online material for c-di AMP Secreted by Intracellular
Listeria monocytogenes Activates a Host Type I Interferon Response", , 27 May 2010
(2010-05-27), XP002750787, Retrieved from the Internet: URL:www.sciencemag.org/cgi/content/full/sc
ience.1189801/DC1 [retrieved on 2015-11-11]
- THOMAS W. DUBENSKY ET AL: "Abstract 4573: STINGVAX - A novel tumor vaccine with cyclic
dinucleotides - can induce potent anti-tumor responses in vivo .", CANCER RESEARCH,
vol. 73, no. 8 Supplement, 15 April 2013 (2013-04-15), pages 4573-4573, XP055226202,
US ISSN: 0008-5472, DOI: 10.1158/1538-7445.AM2013-4573
- BURDETTE ET AL.: 'STING is a direct innate immune sensor of cyclic-di-GMP' NATURE
vol. 478, no. 7, 25 September 2011, pages 515 - 518, XP055177395
- DRIESSENS ET AL.: 'Highly Successful Therapeutic Vaccinations Combining Factor Dendritic
Cells and Tumor Cells Secreting Granulocyte Macrophage Colony-stimulating Factor'
CANCER RESEARCH vol. 64, 15 November 2004, pages 8435 - 8442, XP055177396
- CRITTENDEN ET AL.: 'Expression of inflammatory chemokines combined with local tumor
destruction enhances tumor regression and long-term immunity' CANCER RESEARCH vol.
63, 01 September 2003, pages 5505 - 5512, XP055177397
- CURRAN ET AL.: 'Tumor Vaccines Expressing Flt3 Ligand Synergize with CTLA-4 Blockade
to Reject Preimplanted Tumors' CANCER RESEARCH vol. 69, 08 September 2009, pages 7747
- 7755, XP055177400
- DUBENSKY ET AL.: 'Rationale, progress, and development of vaccines utilizing STING-activating
cyclic dinucleotide adjuvants' THERAPEUTIC ADVANCES IN VACCINES vol. 1, no. 4, 05
September 2013, pages 131 - 143, XP055177403
- FU JUAN ET AL: "STING agonist formulated cancer vaccines can cure established tumors
resistant to PD-1 blockade.", SCIENCE TRANSLATIONAL MEDICINE 15 APR 2015, vol. 7,
no. 283, 15 April 2015 (2015-04-15), page 283ra52, ISSN: 1946-6242
|
|
