(19)

(11)

EP 2 858 984 A1

(12)

(43) Date of publication: 15.04.2015 Bulletin 2015/16 (21) Application number: 13729577.0 (22) Date of filing: 07.06.2013

(51) International Patent Classification (IPC):  C07D 401/04(2006.01) C07D 409/14(2006.01) A61K 31/00(2006.01) C07D 487/06(2006.01) (86) International application number: PCT/US2013/044636 (87) International publication number: WO 2013/184985 (12.12.2013 Gazette 2013/50)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME (30) Priority: 08.06.2012 US 201261657236 P (71) Applicant: Vertex Pharmaceuticals Inc. Boston, MA 02210 (US)

(72) Inventors: CHARIFSON, Paul, S. Framingham, MA 01701 (US) LEDEBOER, Mark, W. Acton, MA 01720 (US) CLARK, Michael, P. Concord, MA 01742 (US) BOYD, Michael, J. Winchester, MA 01890 (US) GAO, Huai Arlington, MA 02474 (US) LEDFORD, Brian Norton, MA 02766 (US) MALTAIS, Francois Tewksbury, MA 01876 (US) PEROLA, Emanuele Brookline, MA 02445 (US) (74) Representative: Cohausz & Florack  Patent- & Rechtsanwälte Partnerschaftsgesellschaft mbB Bleichstraße 14 40211 Düsseldorf 40211 Düsseldorf (DE)